Article
Characterization of Dp71Δ(78-79), a novel dystrophin mutant that stimulates PC12 cell differentiation.
Journal of neurochemistry - 1 Nov 2011
Aragón Jorge, Romo-Yáñez José, Martínez-Herrera Alejandro, Ceja Víctor, Rendon Alvaro, Montañez Cecilia
Abstract excerpt
Dp71 has an important role in the central nervous system. To better understand the function of Dp71 domains in neuronal differentiation, PC12 cells were stably transfected with a dystrophin mutant, Dp71Δ(78-79) , which lacks exons 78 and 79. Based on the percentage of cells bearing neurites and neurite length analyses, we found that cells stably expressing Dp71Δ(78-79) (PC12-C11) differentiate more efficiently...
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