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Mutation of leucine 170 alters the subcellular distribution, neurite outgrowth and three-dimensional structure of dystrophins Dp71 and Dp40.

Molecular biology reports - 13 Mar 2026

García-Cruz César, Sanchez-Perez Luis, Herrera-Rojas Fernanda, Posadas-Trejo Manuel, Ceja Víctor, Sánchez-Trujillo Alejandra, Merino-Jiménez Candelaria, Aragón Jorge, Montanez Cecilia

Abstract excerpt

BACKGROUND: In addition to progressive muscle wasting, one-third of patients with Duchenne muscular dystrophy (DMD) exhibit varying degrees of cognitive impairment, which are associated with mutations of the DMD gene within the region coding for dystrophins Dp71 and Dp40. A previous study reported that the deletion of leucine 3238 in dystrophin Dp427 induces cognitive impairments without muscular dystrophy. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41824108
DOI: 10.1007/s11033-026-11646-9
PMCID: PMC12987883

Genes

DMD
NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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