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ASH2L Deficiency in Smooth Muscle Drives Pulmonary Vascular Remodeling

25 Feb 2025

Abstract excerpt

BACKGROUND: Histone H3 lysine 4 methylation is one of the most abundant epigenetic modifications, which has been recently linked to vascular remodeling in pulmonary hypertension (PH). SET1/MLL methyltransferase complexes comprise the main enzymes responsible for methylating H3 lysine 4, yet their roles in vascular remodeling and PH are not fully understood. We aim to assess the contribution of ASH2L, a core...

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PMID: 39996311
DOI: 10.1161/circresaha.124.325539

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