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Article

Genetic variants in the serotonin transporter influence the efficacy of bupropion and nortriptyline in smoking cessation.

Addiction (Abingdon, England) - 1 Jan 2012

Quaak Marieke, van Schayck Constant P, Postma Dirkje S, Wagena Edwin J, van Schooten Frederik J

Abstract excerpt

AIMS: We investigated whether variants in the serotonin transporter gene (SLC6A4) influence smoking cessation rates using antidepressant therapy (i.e. bupropion and nortriptyline). DESIGN: Pharmacogenetic (secondary) analysis of a randomized, placebo-controlled efficacy trial of bupropion and nortriptyline for smoking cessation. SETTING: Single-centre study, Maastricht University, the Netherlands. PARTICIPANTS: A...

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Identifiers

PMID: 21658141
DOI: 10.1111/j.1360-0443.2011.03534.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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