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Article

Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses.

Drug and alcohol dependence - 1 Nov 2008

David Sean P, Johnstone Elaine C, Murphy Michael F G, Aveyard Paul, Guo Boliang, Lerman Caryn, Munafò Marcus R

Abstract excerpt

The serotonin pathway has been implicated in nicotine dependence and may influence smoking cessation. Therefore, 792 cigarette smokers from the Patch in Practice trial were genotyped for the tryptophan hydroxylase (TPH1 A779C), serotonin transporter (SLC6A45-HTTLPR), and 5-HT1A (HTR1A C-1019G) polymorphisms. Cox regression analysis did not demonstrate significant effects of any of the three genotypes on relapse...

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Source

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Identifiers

PMID: 18562131
DOI: 10.1016/j.drugalcdep.2008.04.013
PMCID: PMC4439462

Genes

TPH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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