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Article

Evaluation of the PC-1 K121Q and G2906C variants as independent risk factors for ischaemic stroke.

Hamostaseologie - 1 Aug 2011

Rieger M, Endler G, Funk M, Lalouschek W, Lang W, Mannhalter C, Sunder-Plassmann R

Abstract excerpt

UNLABELLED: Overexpression of plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor tyrosine kinase activity and thus favours insulin resistance and atherosclerotic vascular disease. Recent findings indicate that the minor variant K121Q in the PC-1 gene confers an increased risk for early myocardial infarction independent of other established risk factors. We hypothesized that genetic variants in...

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PMID: 21647535
DOI: 10.5482/ha-1142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Evaluation of the PC-1 K121Q and G2906C variants as independent risk factors for ischaemic stroke.PMID 21647535Read ↗

The K121Q polymorphism in the plasma cell membrane glycoprotein 1 gene predisposes to early myocardial infarction.Semantic proximity Read ↗

A KQ121 variant in the PC-1 gene and diabetic nephropathy: discrepant results between North and South Europe.Semantic proximity Read ↗

The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.Semantic proximity Read ↗

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.Semantic proximity Read ↗

The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease.Semantic proximity Read ↗

Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia.Semantic proximity Read ↗

K121Q ENPP1/PC-1 gene polymorphism is associated with insulin resistance in a North Indian population.Semantic proximity Read ↗

K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population.Semantic proximity Read ↗

The K121Q polymorphism of ENPP1 and peripheral arterial disease.Semantic proximity Read ↗

A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities.Semantic proximity Read ↗

Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene.Semantic proximity Read ↗

The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.Semantic proximity Read ↗

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