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Notch Signaling in CD66+ Cells Drives the Progression of Human Cervical Cancers

6 Jun 2011

Abstract excerpt

Human epithelial tumor progression and metastasis involve cellular invasion, dissemination in the vasculature, and regrowth at metastatic sites. Notch signaling has been implicated in metastatic progression but its roles have yet to be fully understood. Here we report the important role of Notch signaling in maintaining cells expressing the carcinoembryonic antigen cell adhesion molecule CEACAM (CD66), a known...

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PMID: 21646470
DOI: 10.1158/0008-5472.can-11-0543

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