Article
Decreased expression of lysosomal alpha-galactosiase A gene in sporadic Parkinson's disease.
Neurochemical research - 1 Oct 2011
Wu Guanghua, Huang Jian, Feng Xungang, Zhang Aimei, Li Jifeng, Pang Shuchao, Gu Kejin, Dong Haixin, Zhang Junping, Gao Huijie, Yan Bo
Abstract excerpt
Parkinson's disease (PD) is a progressive neurodegenerative disease. To date, the causal genes and variants associated with sporadic PD are largely unknown. Accumulating evidence demonstrates that autophagy delivers alpha-syncuclein proteins to lysosome for degradation and dysfunctional autophagy is involved in the PD pathogenesis. We have previously screened a group of lysosomal hydrolases and found that...
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