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Article

Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2011

Seriwatanachai Dutmanee, Densmore Michael J, Sato Tadatoshi, Correa Diego, Neff Lynn, Baron Roland, Lanske Beate

Abstract excerpt

Jansen metaphyseal chondrodysplasia (JMC) is caused by a constitutively activating mutation of the parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor (PTHR1) and is characterized by widening of the metaphyses, reduction of long bone length, and short stature. A transgenic mouse expressing this mutation under the collagen α1(II) promoter has been generated to investigate the mechanisms responsible for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21642473
DOI: 10.1096/fj.11-183277
PMCID: PMC3157684

Genes

PTH

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Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia.PMID 21642473Read ↗

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