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Article

Two Novel Determinants of Etoposide Resistance in Small Cell Lung Cancer

3 Jun 2011

Abstract excerpt

Patient survival in small cell lung cancer (SCLC) is limited by acquired chemoresistance. Here we report the use of a biologically relevant model to identify novel candidate genes mediating in vivo acquired resistance to etoposide. Candidate genes derived from a cDNA microarray analysis were cloned and transiently overexpressed to evaluate their potential functional roles. We identified two promising genes in the...

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PMID: 21642373
DOI: 10.1158/0008-5472.can-11-0080

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