Article
Monitoring of in vivo function of superparamagnetic iron oxide labelled murine dendritic cells during anti-tumour vaccination.
PloS one - 1 Jan 2011
Tavaré Richard, Sagoo Pervinder, Varama Gopal, Tanriver Yakup, Warely Alice, Diebold Sandra S, Southworth Richard, Schaeffter Tobias, Lechler Robert I, Razavi Reza, Lombardi Giovanna, Mullen Gregory E D
Abstract excerpt
Dendritic cells (DCs) generated in vitro to present tumour antigens have been injected in cancer patients to boost in vivo anti-tumour immune responses. This approach to cancer immunotherapy has had limited success. For anti-tumour therapy, delivery and subsequent migration of DCs to lymph nodes leading to effective stimulation of effector T cells is thought to be essential. The ability to non-invasively monitor...
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