Article
In vivo imaging of lymph node migration of MNP- and (111)In-labeled dendritic cells in a transgenic mouse model of breast cancer (MMTV-Ras).
Molecular imaging and biology - 1 Apr 2012
Martelli Cristina, Borelli Manuela, Ottobrini Luisa, Rainone Veronica, Degrassi Anna, Russo Micaela, Gianelli Umberto, Bosari Silvano, Fiorini Carlo, Trabattoni Daria, Clerici Mario, Lucignani Giovanni
Abstract excerpt
PURPOSE: The authors present a protocol for the in vivo evaluation, using different imaging techniques, of lymph node (LN) homing of tumor-specific dendritic cells (DCs) in a murine breast cancer model. PROCEDURES: Bone marrow DCs were labeled with paramagnetic nanoparticles (MNPs) or (111)In-oxine. Antigen loading was performed using tumor lysate. Mature DCs were injected into the footpads of transgenic...
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