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Article

Microenvironmental genomic alterations and clinicopathological behavior in head and neck squamous cell carcinoma.

JAMA - 10 Jan 2007

Weber Frank, Xu Yaomin, Zhang Li, Patocs Attila, Shen Lei, Platzer Petra, Eng Charis

Abstract excerpt

CONTEXT: Carcinogens associated with head and neck squamous cell carcinoma (SCC) genesis should inflict genomic alterations not only on the epithelium but also the mesenchyme of the aerodigestive tract. Therefore, the apparently nonmalignant stroma surrounding the tumor epithelium can acquire genomic alterations and contribute to cancer initiation and progression. OBJECTIVES: To determine compartment-specific...

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Identifiers

PMID: 17213402
DOI: 10.1001/jama.297.2.187

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