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Article

Safety and efficacy of a thymidine kinase negative equine herpesvirus-1 vaccine in young horses.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire - 1 Apr 1990

Cornick J, Martens J, Martens R, Crandell R, McConnell S, Kit S

Abstract excerpt

A drug induced equine herpesvirus-1 (EHV-1) mutant lacking thymidine kinase inducing activity was developed and evaluated as a vaccine. The safety and effectiveness of the vaccine to protect against experimentally induced EHV-1 respiratory disease were evaluated in weanling horses free of EHV-1 neutralizing antibody. The vaccine was safe when administered either intramuscularly or intravenously, and EHV-1 was not...

Topics

Animals
Antibodies, Viral
Body Temperature
DNA, Viral
Electrophoresis, Agar Gel
Enzyme Induction
Herpesviridae
Herpesviridae Infections
Herpesvirus 1, Equid
Horse Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Horses

Leukocyte Count

Mutation

Neutrophils

Restriction Mapping

Thymidine Kinase

Vaccination

Viral Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 2162730
PMCID: PMC1255647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2162730-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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