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Article

Potential of Equine Herpesvirus 1 as a Vector for Immunization

12 Apr 2005

Abstract excerpt

Key problems using viral vectors for vaccination and gene therapy are antivector immunity, low transduction efficiencies, acute toxicity, and limited capacity to package foreign genetic information. It could be demonstrated that animal and human cells were efficiently transduced with equine herpesvirus 1 (EHV-1) reconstituted from viral DNA maintained and manipulated in Escherichia coli. Between 13 and 23% of...

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Identifiers

PMID: 15827159
DOI: 10.1128/jvi.79.9.5445-5454.2005

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