Equine herpesvirus type 1 mutant defective in glycoprotein E gene as candidate vaccine strain.

doi:10.1292/jvms.001439

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Article

Equine herpesvirus type 1 mutant defective in glycoprotein E gene as candidate vaccine strain.

The Journal of veterinary medical science - 1 Nov 2009

TSUJIMURA Koji, SHIOSE Tomoki, YAMANAKA Takashi, NEMOTO Manabu, KONDO Takashi, MATSUMURA Tomio

Abstract excerpt

An equine herpesvirus type 1 (EHV-1) mutant, DeltagE, defective in glycoprotein E (gE) was evaluated as a modified live virus (MLV) vaccine. Colostrum-deprived Thoroughbred foals inoculated intranasally (i.n.) or intramuscularly (i.m.) with DeltagE did not exhibit any clinical signs of respiratory disease except for a mild nasal discharge in 1 i.n. inoculated foal on Days 1 and 3 post-infection. In contrast, the...

Topics

Administration, Intranasal
Animals
Gene Expression Regulation, Viral
Herpesviridae Infections
Herpesvirus 1, Equid
Horse Diseases
Horses
Injections, Intramuscular
Mutation
Viral Envelope Proteins
Viral Vaccines

Source

Open in PubMed

Identifiers

PMID: 19959893
DOI: 10.1292/jvms.001439

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