Article
Effect of efflux pump inhibitors on drug susceptibility of ofloxacin resistant Mycobacterium tuberculosis isolates.
The Indian journal of medical research - 1 May 2011
Singh Mradula, Jadaun G P S, Ramdas, Srivastava K, Chauhan Vipin, Mishra Ritu, Gupta Kavita, Nair Surya, Chauhan D S, Sharma V D, Venkatesan K, Katoch V M
Abstract excerpt
BACKGROUND & OBJECTIVES: In drug resistant, especially multi-drug resistant (MDR) tuberculosis, fluoroquinolones (FQs) are used as second line drugs. However, the incidence of FQ-resistant Mycobacterium tuberculosis is rapidly increasing which may be due to extensive use of FQs in the treatment of various other diseases. The most important known mechanism i.e., gyrA mutation in FQ resistance is not observed in a...
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