Article
MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targets.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2011
Abraham Deepak, Jackson Nicole, Gundara Justin S, Zhao JingTing, Gill Anthony J, Delbridge Leigh, Robinson Bruce G, Sidhu Stan B
Abstract excerpt
PURPOSE: While the molecular basis of hereditary medullary thyroid cancer (HMTC) has been well defined, little is known about the molecular pathogenesis of sporadic medullary thyroid cancer (SMTC). In addition, microRNAs (miRNAs) have been shown to be important diagnostic and prognostic markers in cancer but have not been defined in MTC. Our aim was to study the miRNA profile of MTC to identify prognostic...
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