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Article

Sequence variants within the 3'-UTR of the COL5A1 gene alters mRNA stability: implications for musculoskeletal soft tissue injuries.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jun 2011

Laguette Mary-Jessica, Abrahams Yoonus, Prince Sharon, Collins Malcolm

Abstract excerpt

COL5A1 encodes the α1 chain of type V collagen, a quantitatively minor fibrillar collagen that regulates fibrillogenesis. A variant within the 3'-UTR of COL5A1 is associated with chronic Achilles tendinopathy (AT) and other exercise-related phenotypes but the functional significance of this is unknown. The aim of this study was therefore to identify functional differences between the COL5A1 3'-UTR from patients...

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Identifiers

PMID: 21609763
DOI: 10.1016/j.matbio.2011.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequence variants within the 3'-UTR of the COL5A1 gene alters mRNA stability: implications for musculoskeletal soft tissue injuries.PMID 21609763Read ↗

Polymorphisms within the COL5A1 3'-UTR that alters mRNA structure and the MIR608 gene are associated with Achilles tendinopathy.Semantic proximity Read ↗

A polymorphism in a functional region of the COL5A1 gene: association with ultraendurance-running performance and joint range of motion.Semantic proximity Read ↗

Genetic variants within the COL5A1 gene are associated with ligament injuries in physically active populations from Australia, South Africa, and Japan.Semantic proximity Read ↗

The COL5A1 gene is associated with increased risk of carpal tunnel syndrome.Semantic proximity Read ↗

A splice-junction mutation in the region of COL5A1 that codes for the carboxyl propeptide of pro alpha 1(V) chains results in the gravis form of the Ehlers-Danlos syndrome (type I).Semantic proximity Read ↗

The <i>COL5A1</i> genotype is associated with range of motion measurementsSemantic proximity Read ↗

Polymorphisms within the COL5A1 gene and regulators of the extracellular matrix modify the risk of Achilles tendon pathology in a British case-control study.Semantic proximity Read ↗

Null alleles of the COL5A1 gene of type V collagen are a cause of the classical forms of Ehlers-Danlos syndrome (types I and II).Semantic proximity Read ↗

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The COL5A1 gene and Achilles tendon pathology.Semantic proximity Read ↗

Allele dependent silencing of collagen type I using small interfering RNAs targeting 3'UTR Indels - a novel therapeutic approach in osteogenesis imperfecta.Semantic proximity Read ↗

Transcriptome analysis of ageing in uninjured human Achilles tendonSemantic proximity Read ↗

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