Article
Mass spectrometric determination of IgG subclass-specific glycosylation profiles in siblings discordant for myositis syndromes.
Journal of proteome research - 1 Jul 2011
Perdivara Irina, Peddada Shyamal D, Miller Frederick W, Tomer Kenneth B, Deterding Leesa J
Abstract excerpt
Many autoimmune conditions are believed to result from chronic inflammation as a consequence of the interaction of genetic and environmental factors in susceptible individuals. One common feature in some autoimmune diseases is the decrease in terminal galactosylation of the constant region N-glycan of the total plasma immunoglobulin. To determine whether a similar pattern is characteristic for the autoimmune...
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