Article
Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population.
World journal of gastroenterology - 14 Jan 2005
Zhu Zhong-Zheng, Cong Wen-Ming, Liu Shu-Fang, Dong Hui, Zhu Guan-Shan, Wu Meng-Chao
Abstract excerpt
AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53 Arg72Pro polymorphism and susceptibility to hepatocellular carcinoma (HCC) among Chinese population. METHODS: The p53 Arg72Pro genotypes were determined by PCR-based restriction fragment length polymorphism (RFLP) analysis in 507 HCC cases and 541...
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