Article
Genetic associations with sporadic neuroendocrine tumor risk.
Carcinogenesis - 1 Aug 2011
Ter-Minassian Monica, Wang Zhaoxi, Asomaning Kofi, Wu Michael C, Liu Chen-Yu, Paulus Jessica K, Liu Geoffrey, Bradbury Penelope A, Zhai Rihong, Su Li, Frauenhoffer Christine S, Hooshmand Susanne M, De Vivo Immaculata, Lin Xihong, Christiani David C, Kulke Matthew H
Abstract excerpt
Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated with NET risk at a P-value <0.01 in a discovery set of 261 cases and 319 controls. Two of these SNPs were found to...
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