Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes.

doi:10.3109/08916934.2011.576724

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Article

Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes.

Autoimmunity - 1 Dec 2011

Nielsen Lotte B, Vaziri-Sani Fariba, Pörksen Sven, Andersen Marie-Louise M, Svensson Jannet, Bergholdt Regine, Pociot Flemming, Hougaard Philip, de Beaufort Carine, Castaño Luis, Mortensen Henrik B, Lernmark Ake, Hansen Lars

Abstract excerpt

Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact of this genetic variant and the ZnT8Ab on the residual beta-cell function during disease progression the first year...

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PMID: 21604969
DOI: 10.3109/08916934.2011.576724

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