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Article

A modulator domain controlling thermal stability in the Group II chaperonins of Archaea.

Archives of biochemistry and biophysics - 1 Aug 2011

Luo Haibin, Robb Frank T

Abstract excerpt

Archaeal Group II chaperonins (Cpns) are strongly conserved, considering that their growth temperatures range from 23 to 122°C. The C-terminal 15-25 residues are hypervariable, and highly charged in thermophilic species. Our hypothesis is that the C-terminal is a key determinant of stabilization of the Cpn complex. The C-terminus of the Cpn from the hyperthermophile Pyrococcus furiosus was mutated to test this...

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Identifiers

PMID: 21600187
DOI: 10.1016/j.abb.2011.04.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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