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Article

Role of the helical protrusion in the conformational change and molecular chaperone activity of the archaeal group II chaperonin.

The Journal of biological chemistry - 30 Apr 2004

Iizuka Ryo, So Sena, Inobe Tomonao, Yoshida Takao, Zako Tamotsu, Kuwajima Kunihiro, Yohda Masafumi

Abstract excerpt

To elucidate the exact role of the helical protrusion of a group II chaperonin in its molecular chaperone function, three deletion mutants of the chaperonin from a hyperthermophilic archaeum (Thermococcus sp. strain KS-1) lacking one-third, two-thirds, and the whole of the helical protrusion were constructed. The helical protrusion is thought to be substituted for the co-chaperonin GroES of a group I chaperonin...

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Identifiers

PMID: 14978026
DOI: 10.1074/jbc.M400839200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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