Article
Ethnic variation in allele distribution of the androgen receptor (AR) (CAG)n repeat.
Journal of andrology - 1 Jan 2000
Ackerman Christine M, Lowe Lynn P, Lee Hoon, Hayes M Geoffrey, Dyer Alan R, Metzger Boyd E, Lowe William L, Urbanek Margrit
Abstract excerpt
The androgen receptor (AR) is important in reproductive organ development, as well as tissue homeostasis of the pancreas, liver, and skeletal muscle in adulthood. The trinucleotide (CAG)(n) repeat polymorphism in exon 1 of the AR gene is thought to regulate AR activity, with longer alleles conferring reduced receptor activity. Therefore, the evaluation of the allelic distribution of the AR (CAG)(n) repeat in...
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