Article
The GGN and CAG repeat polymorphisms in the exon-1 of the androgen receptor gene are, respectively, associated with insulin resistance in men and with dyslipidemia in women.
The Journal of steroid biochemistry and molecular biology - 1 Feb 2009
Rodríguez-González Germán, Ramírez-Moreno Raquel, Pérez Patricia, Bilbao Cristina, López-Ríos Laura, Díaz-Chico Juan C, Lara Pedro C, Serra-Majem Lluis, Chirino Ricardo, Díaz-Chico B Nicolás
Abstract excerpt
The human androgen receptor (AR) gene possesses two trinucleotide repeats of CAG and GGN in exon-1. The GGN repeat affects the amount of AR protein translated, while the CAG repeat affects the efficiency of AR transcriptionaly. In this study, we have genotyped these polymorphic tracts in a repres...
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