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Article

A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

Human molecular genetics - 1 Nov 2009

Hegele Robert A, Ban Matthew R, Hsueh Neil, Kennedy Brooke A, Cao Henian, Zou Guang Yong, Anand Sonia, Yusuf Salim, Huff Murray W, Wang Jian

Abstract excerpt

Numerous single nucleotide polymorphisms (SNPs) have been found in recent genome wide association studies (GWAS) to be associated with subtle plasma triglyceride (TG) variation in normolipidemic subjects. However, since these GWAS did not specifically evaluate patients with rare disorders of lipoprotein metabolism--'hyperlipoproteinemia' (HLP)--it remains largely unresolved whether any of these SNP determinants...

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Source

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Identifiers

PMID: 19656773
DOI: 10.1093/hmg/ddp361
PMCID: PMC2758142

Genes

ANGPTL3
APOA5
GALNT2
GCKR
TBL2
TRIB1

Variants

rs17321515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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