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Article

A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication.

Journal of virology - 1 May 1991

Weindler F W, Heilbronn R

Abstract excerpt

Herpesviruses are helper viruses for productive adeno-associated virus (AAV) replication. To analyze the herpes simplex virus type 1 (HSV-1) functions mediating helper activity, we coinfected HeLa cells with AAV type 2 (AAV-2) and different HSV-1 mutants defective in individual HSV replication genes. AAV replication was fully accomplished in the absence of HSV DNA replication and thus did not require expression...

Topics

Chromosome Mapping
Dependovirus
Genes, Viral
HeLa Cells
Helper Viruses
Humans
Mutation
Simplexvirus
Virus Replication

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1850024
DOI: 10.1128/JVI.65.5.2476-2483.1991
PMCID: PMC240602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1850024-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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