Article
Planning a genome-wide association study: points to consider.
Annals of medicine - 1 Jan 2011
Hakonarson Hakon, Grant Struan F A
Abstract excerpt
It is well established that genetic diversity combined with specific environmental exposures contributes to disease susceptibility. However, it has turned out to be challenging to isolate the genes underlying the genetic component conferring susceptibility to most complex disorders. Traditional candidate gene and family-based linkage studies, which dominated gene discovery efforts for many years, were largely...
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