Article
Suppressing glucose uptake and acetic acid production increases membrane protein overexpression in Escherichia coli.
Microbial cell factories - 17 May 2011
Bäcklund Emma, Ignatushchenko Marina, Larsson Gen
Abstract excerpt
BACKGROUND: The production of integral membrane spanning proteins (IMP's) constitutes a bottleneck in pharmaceutical development. It was long considered that the state-of-the-art was to produce the proteins as inclusion bodies using a powerful induction system. However, the quality of the protein was compromised and the production of a soluble protein that is incorporated into the membrane from which it is...
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