Article
Association of SPINK5 gene polymorphisms with atopic dermatitis in Northeast China.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 May 2012
Zhao L P, Di Z, Zhang L, Wang L, Ma L, Lv Y, Hong Y, Wei H, Chen H D, Gao X H
Abstract excerpt
BACKGROUND: Defect in the SPINK5 gene is known to be implicated in Netherton syndrome (NS), and has been suggested to be a locus predisposing to atopy in general. Coding polymorphisms in SPINK5 exons 13, 14 and 26 have been reported to be associated with atopic dermatitis (AD), asthma and high level of IgE. OBJECTIVES: To examine whether the SPINK5 gene polymorphisms are associated with AD in Northeast China, and...
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