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Article

Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma.

Genes, chromosomes & cancer - 1 Aug 2011

Bennett Kristi L, Campbell Rebecca, Ganapathi Shireen, Zhou Ming, Rini Brian, Ganapathi Ram, Neumann Hartmut P H, Eng Charis

Abstract excerpt

We recently identified germline methylation of KILLIN, a novel p53-regulated tumor suppressor proximal to PTEN, in >1/3 Cowden or Cowden syndrome-like (CS/CSL) individuals who are PTEN mutation negative. Individuals with germline KILLIN methylation had increased risks of renal cell carcinoma (RCC) over those with PTEN mutations. Therefore, we tested the hypothesis that KILLIN may be a RCC susceptibility gene,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21584899
DOI: 10.1002/gcc.20887
PMCID: PMC3110575

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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