Article
SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer.
International journal of oncology - 1 Aug 2011
Schimanski Carl C, Jordan Mareike, Schlaegel Friederike, Schmidtmann Irene, Lang Hauke, Galle Peter R, Moehler Markus, Gockel Ines
Abstract excerpt
We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR and PCR-RFLP in 69 consecutive fresh-frozen samples of human esophagogastric junction and...
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