Article
Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle.
Circulation - 31 May 2011
Mital Seema, Chung Wendy K, Colan Steven D, Sleeper Lynn A, Manlhiot Cedric, Arrington Cammon B, Cnota James F, Graham Eric M, Mitchell Michael E, Goldmuntz Elizabeth, Li Jennifer S, Levine Jami C, Lee Teresa M, Margossian Renee, Hsu Daphne T
Abstract excerpt
BACKGROUND: We investigated the effect of polymorphisms in the renin-angiotensin-aldosterone system (RAAS) genes on ventricular remodeling, growth, renal function, and response to enalapril in infants with single ventricle. METHODS AND RESULTS: Single ventricle infants enrolled in a randomized trial of enalapril were genotyped for polymorphisms in 5 genes: angiotensinogen, angiotensin-converting enzyme,...
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