Article
ERCC1 and ERCC2 polymorphisms and risk of idiopathic azoospermia in a Chinese population.
Reproductive biomedicine online - 1 Jul 2008
Ji Guixiang, Gu Aihua, Xia Yankai, Lu Chuncheng, Liang Jie, Wang Shoulin, Ma Jun, Peng Yuzhu, Wang Xinru
Abstract excerpt
The ERCC1 (excision repair cross complementation group 1) and ERCC2 (excision repair cross complementation group 2) genes are important in repairing DNA damage and genomic instability in germ cells, and are essential for normal spermatogenesis. It has been verified that polymorphisms of these two genes could alter DNA repair capacity in some phenotypic studies. However, little information is available on these...
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