Article
Electrochemical detection of DNA mutations on a PNA-modified electrode utilizing a single-stranded DNA specific endonuclease.
Chemical communications (Cambridge, England) - 21 Jun 2011
Shin Sujeong, Won Byoung Yeon, Jung Cheulhee, Shin Sung Chul, Cho Dae Yeon, Lee Soo Suk, Park Hyun Gyu
Abstract excerpt
Utilizing a peptide nucleic acid (PNA)-modified electrode and a single-stranded DNA specific endonuclease, a novel electrochemical method to identify DNA mutations has been developed and represents a totally new strategy for the electrochemical diagnosis of human genetic mutations.
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