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CRISPR Inhibition of Prophage Acquisition in Streptococcus pyogenes

6 May 2011

Abstract excerpt

Streptococcus pyogenes, one of the major human pathogens, is a unique species since it has acquired diverse strain-specific virulence properties mainly through the acquisition of streptococcal prophages. In addition, S. pyogenes possesses clustered regularly interspaced short palindromic repeats (CRISPR)/Cas systems that can restrict horizontal gene transfer (HGT) including phage insertion. Therefore, it was of...

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PMID: 21573110
DOI: 10.1371/journal.pone.0019543

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