Article
Intragenic interspecific complementation of glucose 6-phosphate dehydrogenase in human-hamster cell hybrids.
Somatic cell and molecular genetics - 1 Mar 1990
Town M, Athanasiou-Metaxa M, Luzzatto L
Abstract excerpt
A new variant of human glucose 6-phosphate dehydrogenase (G6PD), provisionally designated G6PD Harilaou, was observed in a Greek boy affected by severe hemolytic anemia. G6PD Harilaou was associated with very severe deficiency of enzyme activity, which measured about 1% of normal in the patient's fibroblasts. By fusion of Harilaou fibroblasts with a similarly enzyme-deficient mutant CHO cell line, we have...
Topics
- Alleles
- Animals
- Cell Line
- Cricetinae
- Cricetulus
- DNA
- DNA Restriction Enzymes
- Female
- Fibroblasts
- Gene Expression
- Glucosephosphate Dehydrogenase
- Glucosephosphate Dehydrogenase Deficiency