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Article

Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells.

1 Apr 1990

Abstract excerpt

Interleukin 6 (IL-6) is a potent pleiotropic cytokine, known, among others, to stimulate immunoglobulin production by B cells and to trigger acute-phase protein synthesis by hepatocytes. Similar to IL-1, it is produced by monocytes and macrophages following an inflammatory challenge. Analysis of IL-6 receptor (IL-6R) expression on different human cell lines indicates that dexamethasone could up-regulate the...

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PMID: 2157217
DOI: 10.1073/pnas.87.7.2838

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