Article
Rapid discrimination of oseltamivir-resistant 275Y and -susceptible 275H substitutions in the neuraminidase gene of pandemic influenza A/H1N1 2009 virus by duplex one-step RT-PCR assay.
Journal of medical virology - 1 Jul 2011
Nakauchi Mina, Ujike Makoto, Obuchi Masatsugu, Takashita Emi, Takayama Ikuyo, Ejima Miho, Oba Kunihiro, Konomi Nami, Odagiri Takato, Tashiro Masato, Kageyama Tsutomu
Abstract excerpt
Pandemic influenza A/H1N1 2009 (A/H1N1pdm) virus caused significant outbreaks worldwide last year (2009). A number of oseltamivir-resistant A/H1N1pdm viruses possessing an H275Y substitution in the neuraminidase (NA) protein were reported sporadically in several countries, including Japan, but they were sensitive to zanamivir and did not spread in the community. In this study, to monitor rapidly and simply...
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