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Article

Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2005

Abmayr Simone, Gregorevic Paul, Allen James M, Chamberlain Jeffrey S

Abstract excerpt

The absence of dystrophin in Duchenne muscular dystrophy (DMD) leads to sarcolemmal instability and enhances the susceptibility of muscle fibers to contraction-induced injury. Various viral vectors have been used to deliver mini- and microdystrophin expression cassettes to muscles of dystrophin-deficient mdx mice, significantly increasing both the morphological and the functional properties of the muscles....

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Source

Identifiers

PMID: 16099410
DOI: 10.1016/j.ymthe.2005.04.001

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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