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Article

Impairment in functional capacity as an endophenotype candidate in severe mental illness.

Schizophrenia bulletin - 1 Nov 2012

Harvey Philip D, McClure Margaret M, Patterson Thomas L, McGrath John A, Pulver Ann E, Bowie Christopher R, Siever Larry J

Abstract excerpt

Impairment in everyday functioning (also referred to as "disability") is a central feature of schizophrenia (SZ) and bipolar disorder, as well as other neuropsychiatric conditions. There is a genetic contribution to both SZ and bipolar illness (BPI), and the primary putative determinant of impairments in everyday functioning across these 2 conditions, cognitive impairments, also show substantial heritability and...

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Source

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Identifiers

PMID: 21562142
DOI: 10.1093/schbul/sbr046
PMCID: PMC3494058

Genes

BPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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