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Article

Genome sequencing and analysis of Yersina pestis KIM D27, an avirulent strain exempt from select agent regulation.

PloS one - 29 Apr 2011

Losada Liliana, Varga John J, Hostetler Jessica, Radune Diana, Kim Maria, Durkin Scott, Schneewind Olaf, Nierman William C

Abstract excerpt

Yersinia pestis is the causative agent of the plague. Y. pestis KIM 10+ strain was passaged and selected for loss of the 102 kb pgm locus, resulting in an attenuated strain, KIM D27. In this study, whole genome sequencing was performed on KIM D27 in order to identify any additional differences. Initial assemblies of 454 data were highly fragmented, and various bioinformatic tools detected between 15 and 465 SNPs...

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PMID: 21559501
DOI: 10.1371/journal.pone.0019054
PMCID: PMC3084740

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