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Article

Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.

PloS one - 29 Apr 2011

Winsel Sebastian, Sommer Anette, Eschenbrenner Julia, Mittelstaedt Kevin, Klar Ulrich, Hammer Stefanie, Hoffmann Jens

Abstract excerpt

Sagopilone, an optimized fully synthetic epothilone, is a microtubule-stabilizing compound that has shown high in vitro and in vivo activity against a broad range of human tumor models. We analyzed the differential mechanism of action of sagopilone in non-small cell lung cancer cell lines in vitro. Sagopilone inhibited proliferation of non-small cell lung cancer cell lines at lower nanomolar concentration. The...

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Identifiers

PMID: 21559393
DOI: 10.1371/journal.pone.0019273
PMCID: PMC3084814

Genes

EPO
FAS
MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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