Article
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002
Bergo Martin O, Gavino Bryant, Ross Jed, Schmidt Walter K, Hong Christine, Kendall Lonnie V, Mohr Andreas, Meta Margarita, Genant Harry, Jiang Yebin, Wisner Erik R, Van Bruggen Nicholas, Carano Richard A D, Michaelis Susan, Griffey Stephen M, Young Stephen G
Abstract excerpt
Zmpste24 is an integral membrane metalloproteinase of the endoplasmic reticulum. Biochemical studies of tissues from Zmpste24-deficient mice (Zmpste24(-/-)) have indicated a role for Zmpste24 in the processing of CAAX-type prenylated proteins. Here, we report the pathologic consequences of Zmpste24 deficiency in mice. Zmpste24(-/-) mice gain weight slowly, appear malnourished, and exhibit progressive hair loss....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.