Article
Baseline CD4(+) T-cell counts and weighted background susceptibility scores strongly predict response to maraviroc regimens in treatment-experienced patients.
Antiviral therapy - 1 Jan 2011
Schapiro Jonathan M, Boucher Charles A B, Kuritzkes Daniel R, van de Vijver David A, Llibre Josep M, Lewis Marilyn, Simpson Paul, Delogne Christophe, McFadyen Lynn, Chapman Douglass, Perros Manos, Valdez Hernan, van der Ryst Elna, Westby Mike
Abstract excerpt
BACKGROUND: Maraviroc-containing regimens are known to achieve virological suppression in many treatment-experienced patients. This study aimed to evaluate a more rigorous methodological approach to resistance-response analysis in large clinical studies and to better establish which subpopulations of patients were most likely to benefit from maraviroc by refining and extending previous subgroup analyses from the...
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