Characteristic resistance mechanism of Mycobacterium tuberculosis to DC-159a, a new respiratory quinolone.

doi:10.1128/AAC.00417-10

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Article

Characteristic resistance mechanism of Mycobacterium tuberculosis to DC-159a, a new respiratory quinolone.

Antimicrobial agents and chemotherapy - 1 Aug 2011

Sekiguchi Jun-ichiro, Disratthakit Areeya, Maeda Shinji, Doi Norio

Abstract excerpt

A G88C mutation in GyrA is one of the key alterations by which Mycobacterium tuberculosis mutants acquire DC-159a resistance in vitro. A novel double mutation in GyrA, G88C D94H, conferred high DC-159a resistance. Different mutation patterns in GyrA were demonstrated for DC-159a-resistant mutants and quinolone-resistant multidrug-resistant (QR-MDR) M. tuberculosis isolates, with a mutation either at position 90...

Topics

Aminopyridines
Antitubercular Agents
DNA Gyrase
DNA, Superhelical
Drug Resistance, Bacterial
Fluoroquinolones
Humans
Microbial Sensitivity Tests
Mutation
Mycobacterium tuberculosis
Tuberculosis, Multidrug-Resistant

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Identifiers

PMID: 21555766
DOI: 10.1128/AAC.00417-10
PMCID: PMC3147633

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