Article
Low prevalence of insulin-like growth factor-I gene mutations in human growth disorders.
The Journal of clinical endocrinology and metabolism - 1 Mar 1990
Lajara R, Galgani J P, Dempsher D P, Bier D M, Rotwein P
Abstract excerpt
In an attempt to identify genetic lesions contributing to human growth disorders, we evaluated a prospectively recruited group of children with growth failure for mutations in the insulin-like growth factor-I (IGF-I) gene. Two complementary approaches were used: Southern blot analysis to examine the large scale organization of the gene, and a solution hybridization, nuclease protection assay to identify small...
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