Article
Low prevalence of insulin-like growth factor-I gene mutations in human growth disorders.
The Journal of clinical endocrinology and metabolism - 1 Mar 1990
Lajara R, Galgani J P, Dempsher D P, Bier D M, Rotwein P
Abstract excerpt
In an attempt to identify genetic lesions contributing to human growth disorders, we evaluated a prospectively recruited group of children with growth failure for mutations in the insulin-like growth factor-I (IGF-I) gene. Two complementary approaches were used: Southern blot analysis to examine...
Topics
- Blotting, Southern
- Child
- Chromosome Mapping
- DNA
- DNA Restriction Enzymes
- Dwarfism, Pituitary
- Exons
- Female
- Genes
- Humans
- Insulin-Like Growth Factor I
- Male
- Mutation
- Oligonucleotide Probes
- Polymorphism, Genetic
- RNA, Messenger
- Somatomedins