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Article

IGF-I Receptor Mutations Resulting in Intrauterine and Postnatal Growth Retardation

3 Dec 2003

Abstract excerpt

BACKGROUND: Approximately 10 percent of infants with intrauterine growth retardation remain small, and the causes of their growth deficits are often unclear. We postulated that mutations in the gene for the insulin-like growth factor I receptor (IGF-IR) might underlie some cases of prenatal and postnatal growth failure. METHODS: We screened two groups of children for abnormalities in the IGF-IR gene. In one group...

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PMID: 14657428
DOI: 10.1056/nejmoa010107

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